I had the Endometrial Function Test done as I was going through IVF#3 my first round of IVF at the Sher Institute (SIRM) in NY. When I had my initial consultation with my new doctor at SIRM he thought that my previous failures were a combination of poor egg quality due to extremely high amounts of stimulating drugs and an implantation issue. He felt this way because I had my daughter after two months of trying and conceived again 9 months after she turned 1 which ended in miscarriage at 7 weeks and was only 31.
To look into implantation issues he suggested doing the Endometrial Function Test EFT. This test looks at molecular markers to assess the endometrium's (tissue lining the uterus) potential to support implantation and its ability to contribute to the nutrition of the developing embryo. It is a pretty easy test, it involves taking a biopsy of your uterine lining. We did mine 6 days after I ovulated which for most women would be day 20, for me it was day 28 of my cycle. The test results came in 16 days later and showed that I had Glandular Developmental Arrest. The treatment for this is three months of Depot Lurpon, I couldn't go on it quite yet because I was in the middle of my IVF cycle. We finished the cycle and ended up with 5 frozen blastocysts at which time I immediately went on Depot Lupron (a whole other blog entry in and of itself...the hot flashes were horrible).
After 2.5 months of Depot Lupron I was able to start an FET protocol. We transferred two expanded day 5 blastocysts and still failed. So did this work? It did in a way. Later I had a different and new test done called Endometrial Receptivity Array which showed that my lining was receptive so I think it was worth it as it appeared to clear up the Glandular Developmental Arrest.
To look into implantation issues he suggested doing the Endometrial Function Test EFT. This test looks at molecular markers to assess the endometrium's (tissue lining the uterus) potential to support implantation and its ability to contribute to the nutrition of the developing embryo. It is a pretty easy test, it involves taking a biopsy of your uterine lining. We did mine 6 days after I ovulated which for most women would be day 20, for me it was day 28 of my cycle. The test results came in 16 days later and showed that I had Glandular Developmental Arrest. The treatment for this is three months of Depot Lurpon, I couldn't go on it quite yet because I was in the middle of my IVF cycle. We finished the cycle and ended up with 5 frozen blastocysts at which time I immediately went on Depot Lupron (a whole other blog entry in and of itself...the hot flashes were horrible).
After 2.5 months of Depot Lupron I was able to start an FET protocol. We transferred two expanded day 5 blastocysts and still failed. So did this work? It did in a way. Later I had a different and new test done called Endometrial Receptivity Array which showed that my lining was receptive so I think it was worth it as it appeared to clear up the Glandular Developmental Arrest.